reversed clinical and morphologic characteristicsof idiopathic childhood nephrotic syndrome

MicroRNAs in idiopathic childhood nephrotic syndrome.

Childhood nephrotic syndrome (NS) is associated with an increase in the permeability across the glomerular filtration barrier due to processes that affect the dynamics and permselectivity of the glomerular filtration barrier. This increased permeability leads to an inability to restrict the loss of protein to 100 mg/m body surface per day (1 ). The incidence of idiopathic NS has been reported t...

Unanswered questions in childhood idiopathic nephrotic syndrome

Editorial Implication for health policy/practice/research/medical education: Recent advances in molecular genetics have helped in unraveling the genetic component of idiopathic nephrotic syndrome in children. Similar advances in understanding the environmental triggers and immune defects will help better understand the pathogenesis of the disease. It is hoped that the above advancements will ul...

Childhood Idiopathic Steroid Resistant Nephrotic Syndrome, Different Drugs And Outcome.

BACKGROUND The management of steroid resistant nephrotic syndrome (SRNS) is quite difficult in paediatric patients. Not only the remission is difficult but also these patients are at risk of progression to end stage renal disease (ESRD). The goal of treatment is either to achieve complete remission or even partial remission as it is the most important predictor of disease outcome. METHODS Thi...

Nephrotic syndrome in childhood.

Childhood nephrotic syndromes are most commonly caused by one of two idiopathic diseases: minimal-change nephrotic syndrome (MCNS) and focal segmental glomerulosclerosis (FSGS). A third distinct type, membranous nephropathy, is rare in children. Other causes of isolated nephrotic syndrome can be subdivided into two major categories: rare genetic disorders, and secondary diseases associated with...

Influence of nephrotic state on the infectious profile in childhood idiopathic nephrotic syndrome.

UNLABELLED Patients with idiopathic nephrotic syndrome present alterations in their cellular and humoral immune reactions that predispose them to the development of infectious processes. PURPOSE To characterize the infectious processes in patients with idiopathic nephrotic syndrome. PATIENTS AND METHODS Ninety-two children and adolescents with idiopathic nephrotic syndrome were assessed ret...

The nephrotic syndrome of childhood: immunologic, clinical, and pathologic correlations.